Jump to Recipe Print RecipeThere’s something transcendent about the aroma of a slow-cooked meal wafting through your home, isn’t there? This Slow Cooker Mississippi Pot Roast captures that essence, offering a comforting embrace with every bite. Infused with a savory mix of spices and the tangy zest of pepperoncini peppers, this recipe is the perfect solution for busy weeknights or those looking to meal prep without sacrificing quality. One of its most appealing perks is how effortlessly it transforms a simple beef chuck roast into a fork-tender masterpiece that your family will rave about. Plus, it’s a meal prep dream—just set it and forget it, letting your slow cooker do the heavy lifting! Are you ready to discover the secret to unbeatable flavor and ease in the kitchen? Why is this roast so irresistible? Simplicity at Its Finest: With just a few ingredients, this Slow Cooker Mississippi Pot Roast is incredibly easy to prepare, making it perfect for busy cooks. Endless Flavor Fusion: The savory spices combined with tangy pepperoncini create a taste sensation that infuses the meat with mouthwatering goodness. Fork-Tender Perfection: Slow cooking ensures that the beef chuck roast becomes fall-apart tender, making every bite a delightful experience. Versatile Serving Options: Enjoy it over Instant Pot mashed potatoes or cauliflower mash, and customize your plate to fit any dietary preference. Meal Prep Friendly: Make ahead for the week—store leftovers easily for quick lunches, or freeze for future meals, just waiting to be reheated! Once you’ve tried this roast, you may also love our Slow Cooker Tom or Crock Pot Cheeseburger for more comforting dishes that don’t skimp on flavor! Slow Cooker Mississippi Pot Roast Ingredients For the Roast • Beef Chuck Roast – Choose a well-marbled cut for the best flavor and tenderness. • Butter – Adds richness; substitute with dairy-free butter for a dairy-free option. • Garlic Powder – Enhances flavor; fresh garlic can be used, adding a punch of taste. • Onion Powder – Provides sweetness; opt for fresh onions if you prefer a fresher touch. • Fine Salt – Balances all flavors; adjust according to your dietary needs. For the Seasoning Blend • Dried Parsley – Adds a hint of freshness; feel free to use fresh parsley if available. • Dried Dill – Brings an herbal note; fennel fronds can serve as a milder substitute. For Liquid Ingredients • Beef Broth – Keeps the roast moist while adding richness; vegetable broth works for a vegetarian substitute. • Coconut Aminos – A gluten-free soy sauce alternative; can be replaced with soy sauce if gluten is not a concern. • Peperoncini Juice – A key flavor component that brings tang; be cautious omitting as it alters the dish’s classic flavor. • Whole Peperoncinis – Adds heat and texture; banana peppers can be used if you prefer a milder flavor. Now that you have all the ingredients for this slow cooker Mississippi Pot Roast, you’re ready to create a dish that will warm your family’s hearts and satisfy their hunger! Enjoy the journey of cooking and the delightful aromas that fill your kitchen. Step‑by‑Step Instructions for Slow Cooker Mississippi Pot Roast Step 1: Prepare the Roast Begin by patting the beef chuck roast dry with paper towels to remove excess moisture, allowing for better browning. Place the roast in the center of your slow cooker, ensuring it fits snugly to retain heat and moisture during cooking. This is the foundation for your flavorful Slow Cooker Mississippi Pot Roast. Step 2: Create the Seasoning Rub In a small bowl, combine softened butter with garlic powder, onion powder, fine salt, dried parsley, and dried dill until well-blended. Use your hands to rub this mixture generously over the entire surface of the roast, coating it evenly. This seasoning blend will infuse the meat with rich flavors as it cooks slowly. Step 3: Add Liquids and Peppers Pour the beef broth, coconut aminos, and peperoncini juice around the roast in the slow cooker. This combination will create a savory cooking liquid that enhances the flavors, while maintaining moisture. Top the roast with whole peperoncinis to introduce tangy heat and texture, making the Mississippi Pot Roast unforgettable. Step 4: Set the Slow Cooker Cover the slow cooker with its lid and set it to cook on low for 8-10 hours, or on high for 4-6 hours. If you’re cooking on low, be patient, as this method allows the collagen in the meat to break down, resulting in a fall-apart tender roast. You’ll know it’s ready when it shreds easily with a fork. Step 5: Shred and Serve Once the cooking time is completed, carefully remove the roast from the slow cooker and place it on a cutting board. Using two forks, shred the beef into bite-sized pieces, then return the shredded meat to the slow cooker. Stir it into the cooking juices to keep the flavors combined, making your Slow Cooker Mississippi Pot Roast irresistible! Make Ahead Options Preparing your Slow Cooker Mississippi Pot Roast ahead of time is a fantastic way to save precious time during busy weeknights! You can season the beef chuck roast and place it in the slow cooker liner, then refrigerate it for up to 24 hours before you’re ready to cook. This allows the flavors to meld beautifully. If you’d like, you can also chop your pepperoncini and blend the spices in advance, storing them in the fridge for freshness. When you’re ready to serve, simply pour in your liquids and cook as directed. This make-ahead approach ensures your meal is just as delicious without any last-minute fuss, providing you with a warm, comforting dish your family will love! What to Serve with Slow Cooker Mississippi Pot Roast Elevate your meal with delicious sides that complement the rich flavors of your pot roast, creating a heartwarming feast. Creamy Mashed Potatoes: These velvety potatoes soak up the savory juices from the roast, offering a delightful contrast in texture. Crunchy Roasted Brussels Sprouts: The crispy edges of roasted Brussels sprouts provide a perfect balance to the tender meat, adding an earthy flavor. Tangy Coleslaw: A refreshing coleslaw adds a crunchy bite and acidity, enhancing the rich, savory profile of the pot roast. Flavorful Jasmine Rice: Fluffy jasmine rice is a light and fragrant base that allows the savory flavors to shine deliciously. Savory Garlic Bread: Warm, buttery garlic bread makes for an irresistible addition, perfect for sopping up every last drop of those delicious cooking juices. Zesty Pickled Vegetables: The bright tang of pickles or pickled veggies complements the meat’s richness with a fresh crunch. Chilled White Wine: A crisp, chilled white wine can enhance your meal, providing a refreshing sip between bites of hearty roast. These sides will ensure your Slow Cooker Mississippi Pot Roast shines at the center of a memorable family meal. Expert Tips for Slow Cooker Mississippi Pot Roast Quality Counts: Choose a well-marbled beef chuck roast for the best flavor and tenderness. Low-quality cuts can lead to a tougher result. Season Generously: Don’t skimp on the seasoning rub! The mix of spices and butter is essential for an enticing flavor, so coat the roast fully. Liquid Level: Ensure there’s enough liquid in the slow cooker. If necessary, add a little more beef or vegetable broth, as the cooking process can evaporate some moisture. Cooking Time Matters: Cooking on low for 8-10 hours allows time for the collagen to break down, yielding that luscious fork-tender texture characteristic of a perfect Slow Cooker Mississippi Pot Roast. Mix It Up: Don’t hesitate to experiment with additional vegetables like bell peppers or carrots. They add flavor and nutrition, enhancing your meal’s overall appeal. How to Store and Freeze Slow Cooker Mississippi Pot Roast Fridge: Store leftovers in an airtight container in the refrigerator for up to 5 days. This keeps the flavors intact for quick meals throughout the week. Freezer: For longer storage, freeze the shredded Slow Cooker Mississippi Pot Roast in a freezer-safe container for up to 3 months. This way, you can enjoy this comforting dish anytime! Reheating: Thaw frozen roast overnight in the refrigerator. Reheat gently on the stovetop or in the slow cooker to maintain moisture and flavor—perfect for a quick, hearty dinner! Airtight Storage: Make sure to seal containers properly to prevent freezer burn. This will ensure that you enjoy the same delicious taste when you reheat it! Slow Cooker Mississippi Pot Roast Variations Feel free to get creative and make this Slow Cooker Mississippi Pot Roast your own, delighting your taste buds with every twist! Dairy-Free: Substitute butter with dairy-free butter like Miyoko’s or Earth Balance for a creamy flavor without the dairy. Vegetarian: Use portobello mushrooms instead of beef to create a savory, hearty dish that still captures the essence of the original. Seasoned Veggies: Toss in sliced bell peppers or carrots into the slow cooker for added nutrition and a subtle sweetness. Heat Level Up: Mix in some crushed red pepper flakes with the seasoning or add more pepperoncini peppers to ramp up the heat for spice lovers. Low-Carb Delight: Serve this delicious roast over a bed of cauliflower rice rather than traditional potatoes for a nutritious, low-carb twist. Tangy Kick: Replace peperoncini with sliced jalapeños for a bright and spicy flavor that brings a new dimension to the dish. Extra Savory: For a richer broth, consider enriching it with a splash of red wine—just reduce the amount of beef broth slightly to compensate. Bulk Cooking: Make a double batch for families or meal prepping, and store portions in your freezer for a quick, satisfying dinner fix anytime you need it! Once you’ve enjoyed this satisfying roast, you might also appreciate the comforting flavors of our Slow Cooker Beef or find delight in the hearty goodness of Crock Pot Cheeseburger soup, both perfect for family gatherings or cozy nights at home! Slow Cooker Mississippi Pot Roast Recipe FAQs What kind of beef is best for Mississippi Pot Roast? Absolutely! A well-marbled beef chuck roast is ideal for this recipe, as it delivers the best flavor and tenderness. The fat within the chuck cuts will dissolve during slow cooking, creating that melt-in-your-mouth texture we all love. Feel free to experiment with a brisket or a round roast, but keep in mind that the results may differ in tenderness. How do I store leftover Mississippi Pot Roast? After enjoying your Slow Cooker Mississippi Pot Roast, it’s easy to store leftovers! Simply place them in an airtight container and refrigerate for up to 5 days. This allows for quick, satisfying meals during the week. If you want to keep it longer, follow the freezing instructions below! Can I freeze Slow Cooker Mississippi Pot Roast? Yes, you can! For freezing, let the shredded roast cool completely before transferring it to a freezer-safe container. Seal it tightly and store in the freezer for up to 3 months. To reheat, simply thaw it overnight in the refrigerator, then warm it gently on the stovetop or in a slow cooker with a splash of beef broth to keep it moist. What if my roast is tougher than expected? If your Slow Cooker Mississippi Pot Roast turns out tougher than desired, it may need more cooking time. Ensure it’s cooked on low for the full 8-10 hours, allowing the collagen in the meat to break down fully. If it’s still not fork-tender, try shredding the meat and simmering it in the cooking juices on low heat for an additional 30 minutes—this will help enhance its tenderness. Can I adapt this recipe for dietary restrictions? Very! For a dairy-free version, simply replace the butter with a dairy-free alternative like Miyoko’s or Earth Balance. If you need a gluten-free option, coconut aminos works wonderfully instead of soy sauce. Additionally, keep in mind that the flavor from the peperoncini juice is essential, so avoid removing it unless absolutely necessary! Is Mississippi Pot Roast safe for pets? Be cautious! While the ingredients in your Slow Cooker Mississippi Pot Roast are safe for humans, they often contain seasonings like salt and onions that can be harmful to pets. Always consult your veterinarian before sharing any human food with your furry friends to ensure it’s safe for them. Savory Slow Cooker Mississippi Pot Roast for Family Comfort No ratings yet This Slow Cooker Mississippi Pot Roast is a comforting dish packed with flavor, perfect for effortless family dinners. Print Recipe Pin Recipe Prep Time 15 minutes minsCook Time 10 hours hrsTotal Time 10 hours hrs 15 minutes mins Servings: 6 servingsCourse: DinnerCuisine: AmericanCalories: 400 Ingredients Equipment Method Nutrition Notes Ingredients 1x2x3x? For the Roast3 pounds Beef Chuck Roast Choose a well-marbled cut for best flavor.1/2 cup Butter Substitute with dairy-free butter for dairy-free option.1 tablespoon Garlic Powder Fresh garlic can be used.1 tablespoon Onion Powder Opt for fresh onions if preferred.1 teaspoon Fine Salt Adjust according to dietary needs.For the Seasoning Blend1 tablespoon Dried Parsley Feel free to use fresh parsley if available.1 teaspoon Dried Dill Fennel fronds can serve as a milder substitute.For Liquid Ingredients2 cups Beef Broth Vegetable broth works for a vegetarian substitute.1/4 cup Coconut Aminos Can be replaced with soy sauce if not gluten-free.1/2 cup Peperoncini Juice Alters flavor if omitted.5 pieces Whole Peperoncinis Banana peppers can be used for a milder flavor. Equipment slow cooker Method Step-by-Step InstructionsPat the beef chuck roast dry with paper towels and place it in the center of your slow cooker.Combine softened butter, garlic powder, onion powder, fine salt, dried parsley, and dried dill in a small bowl. Rub this mixture over the roast.Pour beef broth, coconut aminos, and peperoncini juice around the roast in the slow cooker. Top with whole peperoncinis.Cover and cook on low for 8-10 hours or on high for 4-6 hours, until the meat shreds easily with a fork.Once cooked, shred the beef into bite-sized pieces and return it to the slow cooker, stirring it into the juices. Nutrition Serving: 1servingCalories: 400kcalCarbohydrates: 3gProtein: 45gFat: 20gSaturated Fat: 10gPolyunsaturated Fat: 0.5gMonounsaturated Fat: 6gCholesterol: 120mgSodium: 800mgPotassium: 800mgSugar: 1gVitamin A: 500IUVitamin C: 5mgCalcium: 20mgIron: 3mg NotesStore leftovers in an airtight container in the refrigerator for up to 5 days. Freeze for up to 3 months in a freezer-safe container. Tried this recipe?Let us know how it was!